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The generic name of Lasix is furosemide; a loop diuretic with an anthranilic acid derivative used in treating congestive heart failure and edema. It is also used to prevent standard bred and thoroughbred race horses from bleeding during races. It is available in the market as white tablets with 20 mg, 40 mg and 80 mg respectively. It is a white to off-white odorless crystalline powder and insoluble in water but sparingly soluble in alcohol.
The name Lasix is from the phrase last six related to its duration of action. This drug acts by inhibiting the Na-K-2Cl symporter in the thick ascending limp of the loop of Henle. It also abolishes the corticomedullary osmotic gradient and the action on the distal tubules is independent on any inhibitory effect on carbonic anhydrase or aldosterone.
The indications of this drug are the following: - Edema: used in patients with edema associated with congestive heart failure, renal disease and cirrhosis of the liver. It is useful with greater diuretic potential is desired. The initial dose of the drug is 20-80 as a single dose and if needed same dose can be administered 6 to 8 hours after. The dose of Lasix may be carefully up to 600 mg a day in patients having severe edematous states.
- Hypertension: oral form of Lasix may be in adults in treating hypertension alone or with other antihypertensive agents. For hypertensive patients who cannot be controlled by thiazides will also not be controlled with Lasix alone.
This drug can be either injected intravenously or intramuscularly. It can cause electrolyte imbalances and dehydration that includes the loss of calcium, potassium, magnesium and sodium. It is necessary that we should prevent potassium losses. Excessive use of this drug would lead to metabolic alkalosis because of hypochloremia and hypokalemia. Lasiz should be used with caution when taking drugs combined with corticosteroids, trimethoprim sulfa and aminoglycoside antiobiotics as it may increase the risk of electrolytes imbalances.